Most recent one I can think of, for me, was the wildly-unpopular sitcom "Selfie" starring John Cho and Karen Gillan. After a decade of not being able to stomach sitcoms, my wife and I found one that we didn't just like: we loved it. Cho and Gillan were just......... just unbelievably good together.
But it was poorly marketed and nobody understood it. And all the sci-fi fans of Cho and Gillan apparently felt like the leap from Doctor Who and Star Trek to a silly romcom was just too much. But if you can find it's one half-season online somewhere, it's worth it. Makes other sitcoms look like crap.