Shadow of the Colossus
Falling off the third colossi and struggling to get up while his sword comes crashing down. I kept cheering for Wander to get up.
The Contrarian King. This bastard casts Red Wall on himself at the beginning of battle. The skill removes fire weakness from whoever it was cast on. It finally wore off and I used a fire attack which healed him. The Red wall had been a red herring. I remember going "well i'll be..." right before he rampaged me to death.
Dragon Age 2
When your mother slowly turned around while wearing that wedding dress. I kept going "No, they wouldn't, they can't! Holy shit, they did!