Fable never interested me. The only reason I almost played Fable III at all? I almost got the Xbox 360 bundle that had the console, that game, and Halo Reach.
It depends on what you want. Story, or gameplay. Scifi or medieval. ME1 has a great story, but the gameplay (3rd person shooting mechanics) is... well, alright. Not the best, it takes getting used to. If you can handle that, I highly recommend it.