I don't care about how they don't represent geek culture or whatever, I'm not very into that myself. (Although I do find their lack of females interested in comics, video games, tv shows to be highly annoying. They can be intelligent, sure, Amy and Bernadette are smart, but every mention of comics or video games is met with an eye roll from them and a "oh boys with their toys" attitude. Where is the actual female representation?)
The shows attitude towards India also makes me a bit uncomfortable.
Mostly I just hate the character of Sheldon. How to audience practically fall to pieces at the very sight of him, how long he mugs the camera for ages.