Baldur's Gate II - Life... is strength. This is not to be contested; it seems logical enough. You live; you affect your world. But is it what you want? You are... different inside. This woman lives and has strength of a sort. She lost her parents to plague, her husband to war, but she persevered. Her farm has prospered, her name is respected and her children are fed and safe. She lived as she thought she should. And now she is dead. Her land will be divided, her children will move on, and she will be forgotten. She lived a good life, but she had no power; she was a slave to death. I wonder if you are destined to be forgotten. Will your life fade in the shadow of greater beings? - Jon Irenicus
You walk as a mortal, taking no advantage from your heritage, from your talents within. So many things of flesh are greater than you. Walk among them, these beasts that are less than you are. See their strength; see how easily you fall to their muscle and skill. Why do you stand for this? Why do you submit to the flesh when death is bred in your bones? Do you realise the power you might hold? When the world of flesh is beneath you, even creatures mysterious and magical will fall! - Jon Irenicus
Fallout 3 - You Shuffle Stepping, Brain eating, Grave Loving Zombie. Vault Dweller to Mr Crowley.
Luca Blight - "You can round up a million maggots to try to defeat me... but you'll still all just be maggots!"
Everything Lezard Valeth Said in Valkyrie Profile is a great line.
Most everything to come out of Yuri Hyuga's mouth was epic.