This is the only one I'd have ANY DOUBT for, and that's more in case someone's worried about either
Hitler or the fact you have to fight a possessed principle.
Edit: Starmongoose, there are still some companies that are iffy about it, though it seems more relevant when you want to release the game in, say, Germany and have it kept the same there. The other thing I mentioned is more likely to be an issue, but then IS came out around when Columbine happened; it's been 10+ years since and as such I think people will be less touchy there.
... Failing all else, MegaTen's had little trouble dodging any serious controversy.