I'm playing it on 360, probably about 7 hours in. Not really seeing any crazy bugs or game ruining stuff yet, although the game did freeze up on me once when I was running around the Mojave. Maybe it'll get worse, but at this point it's no worse than Fallout 3 was before it was all patched up. I just leave Auto-Save on incase something bad happens and I try to save in any major spots when I haven't auto-saved in awhile. I don't really know why people are complaining about the bugs so much, how about complaining about areas being literally copy/pasted from Fallout 3. Or the graphics not being updated whatsoever at all.
I'm not sure what people expected when they bought this game, but I got exactly what I was expecting. Solild game, more of the same from Fallout 3 and some buggy/glitchyness - but nothing that is ruining the experience thus far.