A lot of what was said in the podcast, and what folks are saying above, I think is valid: fetch quests are definitely the game's undoing in many respects.
I mean, that's what made me hate Fable III.
Also, I think what held true in the podcast about Fallout 3 having much more interesting characterization and style held true as well. However, the big thing to note, is Elder Scrolls and Fallout are completely different things and you shouldn't be looking for the same approaches in each game's development.
I certainly know I'll be playing this game in big spurts (largely Skyward Sword's to blame...) but I find taking a role-play approach will keep it interesting. Now, I don't go crazy hardcore and full D&D all up in this biz, but I give my character a bit of, well, character and make him stick to it. My bosmer is an awesome sneaky archer, but he's no thief. Regardless of how easy it is to steal things, he never will. He also won't follow through on quests that'll wrong the honest folk of the various towns. Finally, he's a hunter, and is now taking to hunting bandits (and goodness knows that population needs controlling) and dragons. He hasn't an ounce of magic in him, won't use a sword, thus I'm sticking to one type of role, regardless of how easy it is to be everything with one character. I'll likely do another runthrough in time with a completely different type of character, who'll take on different quests from the one this dude does. Dunno', maybe I'm too much of a tryhard or D&D kid, but that approach I think adds some better dimensions to the game instead of the initial ADD that Skyrim throws at you with, "OMG teh world are HUGE!" and you run around doing everything.
Pick a path and stick to it, says I *shrugs*
All in all, though, a solid title. The world is really quite breathtaking. I just came upon... uh... Solitude! Yes. Solitude. And it looked so epic, up on that outcropping stone formation? Awesomeness.
Anyways, that's my two cents, but nice reading what everyone else has to say. It's no Skyward Sword, but it still offers something pretty rad to the RPG gamer.
And does anyone else think some invite-only multiplayer would make this sweet?
P.S. Kim might appreciate this, but I can't help but think of how awesome a Harvest Moon with this much scope would be haha. So epic, farming all over Skyrim. Seeing the ranches and farms just planted that thought in my head (and yeah, I know that's also pretty close to Minecraft... but I prefer my Harvest Moon!)