I got a new GPU this Christmas so I believe I'll be able to play it at least at medium settings (high FPS).
The only thing that is making me undecided is that I started Fallout New Vegas and was trying to at least finish the main quest for it first, but since a lot of people, including you guys (the ones I trust when it comes to RPG opinions) say it's this good I think I'll give it another chance. Even if I don't finish it, at least to experience the world and all before Witcher 2 comes out.
@Yggdrasil there's a rumor that this game may actually come to consoles. The way I see it, as Atari is a big publisher and they are releasing it in North America they could make a console version and it would benefit them to do it sooner than later as the end of the year there's Dark Souls and Skyrim.
Given how well Oblivion and Dragon Age did on consoles I couldn't see The Witcher 2 doing much worse.