For those who haven't heard about it, it's the next big title coming from Will Wright of Sims/SimCity/SimX fame.
Here's a google video link from last year's GDC. http://video.google.com/videoplay?docid=8372603330420559198
The speech was stopped mid sentence at the end, perhaps this huge honkin' download is the more complete version. http://www.sporewiki.com/images/media/GDC-Spore.avi
As the GDC presentation commences, I found myself wowed by every step foward he put. In fact, I call him a madman.(only out of jealousy)
The idea of bringing up and manipulating a single celled organism, to a fully intelligent and heavily armed force in the galaxy is well... just mind bending. In fact, I'd argue it'd make a lot of the gaming industry look quite primitive and dull.
The Wikipedia entry lists a possible rumored
release date of late 2006(I really doubt it). We can expect to see and learn more of the title at the next E3, and probably even more at GDC.