| Game | Platform | Developer | Publisher (JP) | Publisher (NA) | Publisher (PAL) |
|---|---|---|---|---|---|
| Sakura Taisen 3: Is Paris Burning? | Microsoft Windows, Sega Dreamcast, Sony PlayStation 2 | Overworks, RED Entertainment, SEGA | SEGA | N/A | N/A |
| Sakura Taisen 4: Maidens, Fall in Love | Microsoft Windows, Sega Dreamcast | Overworks, RED Entertainment, SEGA | SEGA | N/A | N/A |
| Sakura Taisen GB: Geki Hanagumi Nyuutai! | Nintendo Game Boy Color | Jupiter | Media Factory, SEGA | N/A | N/A |
| Sakura Taisen Monogatari: Mysterious Paris | Sony PlayStation 2 | RED Entertainment, SEGA | SEGA | N/A | N/A |
| Sakura Taisen V Episode 0: Kouya no Samurai Musume | Sony PlayStation 2 | RED Entertainment, SEGA | SEGA | N/A | N/A |
| Sakura Taisen: Atsuki Chishio Ni | Sony PlayStation 2 | Overworks, RED Entertainment, SEGA | SEGA | N/A | N/A |
| Sakura Wars (2020) | Sony PlayStation 4 | RED Entertainment, SEGA | SEGA | SEGA | SEGA |
| Sakura Wars ~So Long, My Love~ | Nintendo Wii, Sony PlayStation 2 | RED Entertainment, SEGA | SEGA | NIS America | NIS America |
| Salt and Sacrifice | Microsoft Windows, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Ska Studios | Ska Studios | Ska Studios | Ska Studios |
| Salt and Sanctuary | Linux, Microsoft Windows, Nintendo Switch, Sony PS Vita, Sony PlayStation 4, macOS | Ska Studios | Ska Studios | Ska Studios | Ska Studios |
| Saltsea Chronicles | Microsoft Windows, Nintendo Switch, Sony PlayStation 5, macOS | Die Gute Fabrik | N/A | Die Gute Fabrik | Die Gute Fabrik |
| Salty Hounds | Microsoft Windows, Nintendo Switch, macOS | Topping Palette | N/A | Topping Palette | Topping Palette |
| Sam & Max Save the World – Remastered | Microsoft Windows, Nintendo Switch | Skunkape Games | N/A | Skunkape Games | Skunkape Games |
| Sam & Max: The Devil’s Playhouse | Microsoft Windows, Sony PlayStation 3, iOS, macOS | Telltale Games | N/A | Telltale Games | Telltale Games |
| Sam & Max: The Devil’s Playhouse Remastered | Microsoft Windows, Microsoft Xbox One, Nintendo Switch, Sony PlayStation 4 | Skunkape Games | N/A | Skunkape Games | Skunkape Games |
| Samurai Bringer | Microsoft Windows, Nintendo Switch, Sony PlayStation 4 | ALPHAWING Inc. | PLAYISM | PLAYISM | PLAYISM |
| Samurai Warriors 5 | Microsoft Windows, Microsoft Xbox One, Nintendo Switch, Sony PlayStation 4 | Koei Tecmo Games, Omega Force | Koei Tecmo Games | Koei Tecmo Games | Koei Tecmo Games |
| Sanctus Mortem | Linux, Microsoft Windows, macOS | Kisareth Studios | N/A | Kisareth Studios | Kisareth Studios |
| Sand Land | Microsoft Windows, Microsoft Xbox Series X|S, Sony PlayStation 4, Sony PlayStation 5 | ILCA | Bandai Namco Entertainment | Bandai Namco Entertainment | Bandai Namco Entertainment |
| Sandara: City of a Thousand Eclipses | Microsoft Windows | Studio Malosi | N/A | Studio Malosi | Studio Malosi |
| Sands of Aura | Microsoft Windows | Chashu Entertainment | N/A | indie.io | indie.io |
| Sands of Destruction | Nintendo DS | Imageepoch | SEGA | SEGA | N/A |
| Saturday Morning RPG | Android, Linux, Microsoft Windows, Microsoft Xbox One, Nintendo Switch, Ouya, Sony PS Vita, Sony PlayStation 4, iOS, macOS | Mighty Rabbit Studios | Mighty Rabbit Studios | Mighty Rabbit Studios | Mighty Rabbit Studios |
| Save Your Mother | Microsoft Windows | Tuomo's Games | N/A | Tuomo's Games | Tuomo's Games |
| Saviors of Sapphire Wings / Stranger of Sword City Revisited | Microsoft Windows, Nintendo Switch | Experience | Experience | NIS America | NIS America |
