| Game | Platform | Developer | Publisher (JP) | Publisher (NA) | Publisher (PAL) |
|---|---|---|---|---|---|
| Senkai Taisen: TV Animation Senkaiden Fuukami Engiyori | Sony PlayStation | Opera House | Bandai Namco Entertainment | N/A | N/A |
| Senritsu no Stratus | Sony PSP | Nude Maker | Konami | N/A | N/A |
| Sentimental Graffiti 2 | Microsoft Windows, Sega Dreamcast | Interchannel | Interchannel | N/A | N/A |
| Septerra Core: Legacy of the Creator | Linux, Microsoft Windows, macOS | Valkyrie Studios | N/A | Monolith Productions, TopWare Interactive | Monolith Productions, TopWare Interactive |
| Serial World | Linux, Microsoft Windows, macOS | SerialProject | Kakehashi Games | Kakehashi Games | Kakehashi Games |
| Serious Sam: The Random Encounter | Microsoft Windows | Vlambeer | N/A | Devolver Digital | Devolver Digital |
| Seven: Molmorth no Kiheitai | Sony PlayStation 2 | Bandai Namco Entertainment | Bandai Namco Entertainment | N/A | N/A |
| Seven: The Days Long Gone | Microsoft Windows | Fool's Theory, IMGN.PRO | N/A | IMGN.PRO | IMGN.PRO |
| Seventh Cross: Evolution | Sega Dreamcast | Interchannel | Interchannel | UFO Interactive Games | N/A |
| Shades of Rayna | Microsoft Windows | QuickSave | N/A | QuickSave | QuickSave |
| Shadow Fate | Microsoft Windows | HuntingSwan | N/A | HuntingSwan | HuntingSwan |
| Shadow Gambit: The Cursed Crew | Microsoft Windows, Microsoft Xbox Series X|S, Sony PlayStation 5 | Mimimi Games | Mimimi Games | Mimimi Games | Mimimi Games |
| Shadow Hearts | Sony PlayStation 2 | Nautilus | Aruze | Midway | Midway |
| Shadow Hearts: Covenant | Sony PlayStation 2 | Nautilus | Aruze | Midway | Midway |
| Shadow Hearts: From The New World | Sony PlayStation 2 | Nautilus | Aruze | XSEED Games | Ghostlight |
| Shadow Madness | Microsoft Windows, Sony PlayStation | Crave Entertainment | N/A | Bleem!, Crave Entertainment, Piko Interactive | Bleem!, Crave Entertainment, Piko Interactive |
| Shadow of Destiny | Microsoft Windows, Microsoft Xbox, Sony PSP, Sony PlayStation 2 | Konami | Konami | Konami | Konami |
| Shadow Realms [Cancelled] | Microsoft Windows | BioWare | N/A | N/A | N/A |
| Shadow Spell Saga: The Winds of Fate | Microsoft Windows | Evan C Weber | N/A | Evan C Weber | Evan C Weber |
| Shadowbane | Microsoft Windows, macOS | Stray Bullet Games, Wolfpack Studios | N/A | Ubisoft | Ubisoft |
| Shadowbane: The Rise of Chaos | Microsoft Windows, macOS | Stray Bullet Games, Wolfpack Studios | N/A | Ubisoft | Ubisoft |
| ShadowFlare | Microsoft Windows | Denusha | Emurasoft | Emurasoft | N/A |
| Shadowgate | Microsoft Windows, Nintendo Entertainment System, Nintendo Game Boy Color, macOS | Icom Simulations | N/A | KEMCO, Mindscape | N/A |
| Shadowgate (2014) | Linux, Microsoft Windows, iOS, macOS | Zojoi | N/A | Reverb Triple XP, Zojoi | Reverb Triple XP, Zojoi |
| Shadowgate 64: Trials of the Four Towers | Nintendo 64 | Infinite Ventures | KEMCO | KEMCO | KEMCO |
