| Game | Platform | Developer | Publisher (JP) | Publisher (NA) | Publisher (PAL) |
|---|---|---|---|---|---|
| Empyre: Lords of the Sea Gates | Microsoft Windows | Coin Operated Games | N/A | Coin Operated Games, Work Shift Play | Coin Operated Games, Work Shift Play |
| Empyreal | Microsoft Windows, Microsoft Xbox Series X|S, Sony PlayStation 5 | Silent Games | Secret Mode | Secret Mode | Secret Mode |
| Encased | Microsoft Windows | Dark Crystal Games | N/A | Prime Matter | Prime Matter |
| Enchanted Arms | Microsoft Xbox 360, Sony PlayStation 3 | FromSoftware | FromSoftware | Ubisoft | Ubisoft |
| Encodya | Linux, Microsoft Windows, Microsoft Xbox One, Nintendo Switch, Sony PlayStation 4, macOS | Chaosmonger Studio | N/A | Assemble Entertainment | Assemble Entertainment |
| End of Serenity | Sony PSP | KEMCO | KEMCO | Natsume | N/A |
| ENDER LILIES: Quietus of the Knights | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Adglobe, Live Wire | Binary Haze Interactive | Binary Haze Interactive | Binary Haze Interactive |
| ENDER MAGNOLIA: Bloom in the Mist | Microsoft Windows, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Adglobe, Live Wire | Binary Haze Interactive | Binary Haze Interactive | Binary Haze Interactive |
| Endless Dreams | |||||
| Endless Dungeon | Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Amplitude Studios | SEGA | SEGA | SEGA |
| Energy Breaker | Super Nintendo Entertainment System | Neverland | Taito | N/A | N/A |
| Entaku no Seito: Students of Round | Microsoft Windows, Microsoft Xbox 360 | Experience | Experience | N/A | N/A |
| Entaku no Seito: Students of Round – The Eternal Legend | Sony PSP | Experience | Kadokawa Games | N/A | N/A |
| Entropy | Microsoft Windows | Lovely Hellplace | N/A | DreadXP | DreadXP |
| Eon Altar | Microsoft Windows, macOS | Flying Helmet Games | N/A | Flying Helmet Games | Flying Helmet Games |
| Epanalepsis | Linux, Microsoft Windows, macOS | Cameron Kunzelman | N/A | Cameron Kunzelman | Cameron Kunzelman |
| Ephemeral Fantasia | Sony PlayStation 2 | Konami | Konami | Konami | Konami |
| Epic Quest of the 4 Crystals | Microsoft Windows | RosePortal Games | N/A | Aldorlea Games | Aldorlea Games |
| Epic Seven | Android, iOS | Super Creative | Smilegate Megaport | Smilegate Megaport | Smilegate Megaport |
| Eredia: The Diary of Heroes | Microsoft Windows | Potatobrain Games | N/A | Potatobrain Games | Potatobrain Games |
| Escape Academy | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Sony PlayStation 4, Sony PlayStation 5 | Coin Crew Games, iam8bit | N/A | Skybound Games, iam8bit | Skybound Games |
| Escape Academy 2: Back 2 School | Microsoft Windows | Coin Crew Games | iam8bit | iam8bit | iam8bit |
| Escape from Deathmark Dungeon | Microsoft Windows | Matt Lloyd | N/A | Matt Lloyd | Matt Lloyd |
| Escape from Ever After | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 5 | Sleepy Castle Studio | HypeTrain Digital | HypeTrain Digital | HypeTrain Digital |
| Escape From Monkey Island | Microsoft Windows, Sony PlayStation 2, macOS | LucasArts | N/A | LucasArts | LucasArts |
