| Game | Platform | Developer | Publisher (JP) | Publisher (NA) | Publisher (PAL) |
|---|---|---|---|---|---|
| Escape From Monkey Island | Microsoft Windows, Sony PlayStation 2, macOS | LucasArts | N/A | LucasArts | LucasArts |
| Eschalon: Book II | Linux, Microsoft Windows, macOS | Basilisk Games | N/A | Basilisk Games | Basilisk Games |
| Eselmir and the Five Magical Gifts | Microsoft Windows, macOS | Stelex Software | N/A | Stelex Software | Stelex Software |
| Esoteric Ebb | Microsoft Windows | Christoffer Bodegård | N/A | Raw Fury | Raw Fury |
| Esper Dream | Famicom Disk System, Mobile, Nintendo 3DS, Nintendo Wii, Nintendo Wii U | Konami | Konami | N/A | N/A |
| Esper Dream 2: Aratanaru Tatakai | Nintendo Entertainment System | Konami | Konami | N/A | N/A |
| Esperia ~Uprising of the Scarlet Witch~ | Microsoft Windows | Prismalice | N/A | Prismalice | Prismalice |
| Eternal Eden | Microsoft Windows | Blossomsoft | N/A | Blossomsoft | Blossomsoft |
| Eternal Eden: Ecclesia [Cancelled] | Microsoft Windows | Blossomsoft | N/A | N/A | N/A |
| Eternal Eyes | Sony PlayStation | Sunsoft, TamTam | Sunsoft | Crave Entertainment | N/A |
| Eternal Legacy HD | Android, iOS | Gameloft | N/A | Gameloft | Gameloft |
| Eternal Poison | Sony PlayStation 2 | Flight-Plan | Banpresto | Atlus | N/A |
| Eternal Radiance | Microsoft Windows, Nintendo Switch, Sony PlayStation 4 | Visualnoveler | Visualnoveler | Visualnoveler | Visualnoveler |
| Eternal Remnant: The First Chapter | Microsoft Windows | Arcfinder Studios | N/A | Arcfinder Studios | Arcfinder Studios |
| Eternal Ring | Sony PlayStation 2 | FromSoftware | FromSoftware | Agetec | Crave Entertainment, Ubisoft |
| Eternal Sonata | Microsoft Xbox 360, Sony PlayStation 3 | tri-Crescendo | Bandai Namco Entertainment | Bandai Namco Entertainment | Bandai Namco Entertainment |
| Eternal Strands | Microsoft Windows, Microsoft Xbox Series X|S, Sony PlayStation 5 | Yellow Brick Games | Yellow Brick Games | Yellow Brick Games | Yellow Brick Games |
| Eternights | Microsoft Windows, Sony PlayStation 4, Sony PlayStation 5 | Studio Sai | Studio Sai | Studio Sai | Studio Sai |
| Eternity – The Last Unicorn | Microsoft Windows, Microsoft Xbox One, Sony PlayStation 4 | Void Studios | N/A | Fulqrum Publishing | Fulqrum Publishing |
| Ether One | Microsoft Windows | White Paper Games | N/A | White Paper Games | White Paper Games |
| Ether Saga Odyssey | Microsoft Windows | Perfect World Entertainment | N/A | Perfect World Entertainment | Perfect World Entertainment |
| Etheria: Restart | Android, Microsoft Windows, iOS | XD | XD | XD | XD |
| Etrange Overlord | Microsoft Windows, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Broccoli, Gemdrops, Superniche | Nippon Ichi Software | NIS America | NIS America |
| Etrian Mystery Dungeon | Nintendo 3DS | Atlus, Spike Chunsoft | Atlus | Atlus | NIS America |
| Etrian Odyssey | Nintendo DS | Atlus, Lancarse | Atlus | Atlus | Atlus |
