| Game | Platform | Developer | Publisher (JP) | Publisher (NA) | Publisher (PAL) |
|---|---|---|---|---|---|
| Shiren the Wanderer: The Tower of Fortune and the Dice of Fate | Nintendo DS, Sony PS Vita | Spike Chunsoft | Spike Chunsoft | Aksys Games | N/A |
| Shiren the Wanderer: The Tower of Fortune and the Dice of Fate (2020) | Microsoft Windows, Nintendo Switch | Spike Chunsoft | Spike Chunsoft | Spike Chunsoft | Spike Chunsoft |
| Shironeko New Project | Nintendo Switch | Colopl | Colopl | N/A | N/A |
| Shizuku | MS-DOS, Microsoft Windows, NEC PC-98 | Leaf | Aquaplus, Leaf | N/A | N/A |
| Showa American Story | Microsoft Windows, Sony PlayStation 5 | Nekcom Games | 2P Games | 2P Games | 2P Games |
| Shrine’s Legacy | Microsoft Windows | Positive Concept Games | N/A | indie.io | indie.io |
| Shroud of the Avatar: Forsaken Virtues | Linux, Microsoft Windows, macOS | Portalarium | N/A | Portalarium | Portalarium |
| Shuffle Tactics | Microsoft Windows | Club Sandwich | The Arcade Crew | The Arcade Crew | The Arcade Crew |
| Shujinkou | Microsoft Windows, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5, macOS | Rice Games | N/A | Rice Games | Rice Games |
| Shuten Order | Microsoft Windows, Nintendo Switch | Too Kyo Games | DMM Games, Spike Chunsoft | DMM Games, Spike Chunsoft | DMM Games, Spike Chunsoft |
| Sigh of the Abyss: Shadow Bonds | Microsoft Windows | Rascal Devworks | N/A | Rascal Devworks | Rascal Devworks |
| Sigma Harmonics | Nintendo DS | Square Enix, Think Garage | Square Enix | N/A | N/A |
| Sigma Star Saga | Microsoft Windows, Nintendo Game Boy Advance | WayForward | N/A | Bandai Namco Entertainment | Atari |
| Silence | Linux, Microsoft Windows, Microsoft Xbox One, Nintendo Switch, Sony PlayStation 4, macOS | Daedalic Entertainment | N/A | Daedalic Entertainment | Daedalic Entertainment |
| Silence of the Sleep | Android, Microsoft Windows, iOS, macOS | Jesse Makkonen | N/A | Jesse Makkonen | Jesse Makkonen |
| Silent Hope | Microsoft Windows, Nintendo Switch | Marvelous Entertainment | Marvelous Entertainment | XSEED Games | Marvelous Entertainment |
| Silent Planet – Elegy of a Dying World | Microsoft Windows | Vertex Zero | N/A | Red Dunes Games | Red Dunes Games |
| Silkroad Online | Microsoft Windows | Joymax | N/A | Joymax | Joymax |
| Silver | Linux, Microsoft Windows, Sega Dreamcast, macOS | Spiral House | N/A | Infogrames | Infogrames |
| Silver Nornir | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | WorldWideSoftware | KEMCO | KEMCO | KEMCO |
| Silver Palace | Elementa | N/A | Elementa | Elementa | |
| Silverfall | Microsoft Windows, Sony PSP | Monte Cristo | N/A | Atari | Atari |
| Sin Slayers: Reign of the 8th | Linux, Microsoft Windows, macOS | Goonswarm Games | Goonswarm Games | Goonswarm Games | Goonswarm Games |
| SINce Memories: Off the Starry Sky | Microsoft Windows, Nintendo Switch, Sony PlayStation 4 | Mages | Mages | PQube | PQube |
| Singularity: Tactics Arena | Microsoft Windows, macOS | A Memory of Eternity | N/A | A Memory of Eternity | A Memory of Eternity |
