| Game | Platform | Developer | Publisher (JP) | Publisher (NA) | Publisher (PAL) |
|---|---|---|---|---|---|
| Scar of the Doll | Microsoft Windows | Child-Dream | Degica | Degica | Degica |
| Scarlet Blade | Microsoft Windows | Liveplex | N/A | Aeria Games | Aeria Games |
| Scarlet Hollow | Microsoft Windows, macOS | Black Tabby Games | N/A | Black Tabby Games | Black Tabby Games |
| Scarlet Nexus | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Sony PlayStation 4, Sony PlayStation 5 | Bandai Namco Entertainment | Bandai Namco Entertainment | Bandai Namco Entertainment | Bandai Namco Entertainment |
| Scarlett and the Spark of Life: Scarlett Adventures Episode 1 | iOS | Launching Pad Games | N/A | Launching Pad Games | N/A |
| Scars of Mars | Microsoft Windows | Acquire | Acquire | Acquire | Acquire |
| Science Girls! | Linux, Microsoft Windows, macOS | Spiky Caterpillar | N/A | Hanako Games | Hanako Games |
| Scott Pilgrim EX | Linux, Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Tribute Games | Tribute Games | Tribute Games | Tribute Games |
| SD Gundam Battle Alliance | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Bandai Namco Entertainment | Bandai Namco Entertainment | Bandai Namco Entertainment | Bandai Namco Entertainment |
| SD Gundam G Generation Cross Rays | Microsoft Windows, Nintendo Switch, Sony PlayStation 4 | Tom Create | Bandai Namco Entertainment | Bandai Namco Entertainment | Bandai Namco Entertainment |
| Sea Fantasy | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 5 | METASLA | METASLA | METASLA | METASLA |
| Sea Horizon | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | 45 Studio | SOFTSTAR ENTERTAINMENT | Eastasiasoft, SOFTSTAR ENTERTAINMENT | Eastasiasoft, SOFTSTAR ENTERTAINMENT |
| Sea of Remnants | Android, Microsoft Windows, Sony PlayStation 5, iOS | Joker Studio | NetEase Games | NetEase Games | NetEase Games |
| Sea of Stars | Android, Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5, iOS | Sabotage Studio | Sabotage Studio | Sabotage Studio | Sabotage Studio |
| SEASON: A letter to the future | Microsoft Windows, Sony PlayStation 4, Sony PlayStation 5 | Scavengers Studio | N/A | Scavengers Studio | Scavengers Studio |
| Secret of Evermore | Super Nintendo Entertainment System | Square Enix | N/A | Square Enix | Square Enix |
| Secret of Mana | Nintendo Wii, Nintendo Wii U, Super NES Classic Edition, Super Nintendo Entertainment System | Square Enix | Square Enix | Square Enix | Square Enix |
| Secret of Mana (2010) | Android, iOS | Square Enix | Square Enix | Square Enix | Square Enix |
| Secret of Mana (2018) | Microsoft Windows, Sony PS Vita, Sony PlayStation 4 | Square Enix | Square Enix | Square Enix | Square Enix |
| Secret of the Stars | Super Nintendo Entertainment System | Koei Tecmo Games | Koei Tecmo Games | Koei Tecmo Games | N/A |
| Secrets of Grindea | Microsoft Windows | Pixel Ferrets | N/A | Pixel Ferrets | Pixel Ferrets |
| Seed of Nostalgia | Microsoft Windows, Microsoft Xbox One, Microsoft Xbox Series X|S, Nintendo Switch, Sony PlayStation 4, Sony PlayStation 5 | Primitive Pixels Game Studio | N/A | Primitive Pixels Game Studio | Primitive Pixels Game Studio |
| Seiken Densetsu 3 | Super Nintendo Entertainment System | Square Enix | Square Enix | N/A | N/A |
| Seima Densetsu 3×3 Eyes | Sega CD | Overworks, SEGA | SEGA | N/A | N/A |
| Sekaiju to Fushigi no Dungeon 2 | Nintendo 3DS | Atlus, Spike Chunsoft | Atlus | N/A | N/A |
